| Product Name | mGluR-4 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GRM4 antibody; GPRC1D antibody; MGLUR4 antibody; Metabotropic glutamate receptor 4 antibody; mGluR4 antibody; |
| Product description | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this |
| Immunogen | The antiserum was produced against synthesized peptide derived from human mGluR4. AA range:851-900 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | GRM4 antibody GPRC1D antibody MGLUR4 antibody Metabotropic glutamate receptor 4 antibody mGluR4 antibody |
|---|---|
| Molecular Weight(MW) | 100 kDa |
| SwissProt ID | Q14833 |
|---|
| Positive Control | Brain,Pooled, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
