| Product Name | MKP-1/2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DUSP1 antibody; CL100 antibody; MKP1 antibody; PTPN10 antibody; VH1 antibody; Dual specificity protein phosphatase 1 antibody; Dual specificity protein phosphatase hVH1 antibody; Mitogen-activated protein kinase phosphatase 1 antibody; MAP kinase phosphatase 1 antibody; MKP-1 antibody; Protein-tyrosine phosphatase CL100 antibody; DUSP4 antibody; antibody; |
| Product description | The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferati |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MKP-1/2. AA range:261-310 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | DUSP1 antibody CL100 antibody MKP1 antibody PTPN10 antibody VH1 antibody Dual specificity protein phosphatase 1 antibody Dual specificity protein phosphatase hVH1 antibody Mitogen-activated protein kinase phosphatase 1 antibody MAP kinase phosphatase 1 antibody MKP-1 antibody Protein-tyrosine phosphatase CL100 antibody DUSP4 antibody antibody |
|---|---|
| Molecular Weight(MW) | 41 kDa |
| Positive Control | Brain,Foreskin,Prostate, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
