| Product Name | N-Shc |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SHC3 antibody; NSHC antibody; SHCC antibody; SHC-transforming protein 3 antibody; Neuronal Shc antibody; N-Shc antibody; Protein Rai antibody; SHC-transforming protein C antibody; Src homology 2 domain-containing-transforming protein C3 antibody; SH2 domain protein C3 antibody; |
| Product description | Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. PTM:Tyrosine phosphorylated. Contains 1 PID domain. Contains 1 SH2 domain. subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. tissue specificity:Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SHC3. AA range:291-340 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | SHC3 antibody NSHC antibody SHCC antibody SHC-transforming protein 3 antibody Neuronal Shc antibody N-Shc antibody Protein Rai antibody SHC-transforming protein C antibody Src homology 2 domain-containing-transforming protein C3 antibody SH2 domain protein C3 antibody |
|---|---|
| Molecular Weight(MW) | 48 kDa |
| SwissProt ID | Q92529 |
|---|
| Positive Control | Brain,Fetal brain, |
|---|---|
| Application Notes | IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
