| Product Name | NUB1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NUB1 antibody; NYREN18 antibody; NEDD8 ultimate buster 1 antibody; Negative regulator of ubiquitin-like proteins 1 antibody; Renal carcinoma antigen NY-REN-18 antibody; |
| Product description | This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splici |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NYREN18. AA range:566-615 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouseMonkey |
| Concentration | 1mg/ml |
| Alternative Names | NUB1 antibody NYREN18 antibody NEDD8 ultimate buster 1 antibody Negative regulator of ubiquitin-like proteins 1 antibody Renal carcinoma antigen NY-REN-18 antibody |
|---|---|
| Molecular Weight(MW) | 70 kDa |
| SwissProt ID | Q9Y5A7 |
|---|
| Positive Control | Heart,Renal cell carcinoma,Retina,Testis, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
