| Product Name | ORC1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ORC1 antibody; ORC1L antibody; PARC1 antibody; Origin recognition complex subunit 1 antibody; Replication control protein 1 antibody; |
| Product description | The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcr |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ORC1L. AA range:331-380 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | ORC1 antibody ORC1L antibody PARC1 antibody Origin recognition complex subunit 1 antibody Replication control protein 1 antibody |
|---|---|
| Molecular Weight(MW) | 100120 kDa |
| SwissProt ID | Q13415 |
|---|
| Positive Control | Epithelium,Eye, |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
