| Product Name | p15 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CDKN2B antibody; MTS2 antibody; Cyclin-dependent kinase 4 inhibitor B antibody; Multiple tumor suppressor 2 antibody; MTS-2 antibody; p14-INK4b antibody; p15-INK4b antibody; p15INK4B antibody; |
| Product description | This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human p15 INK. AA range:89-138 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | CDKN2B antibody MTS2 antibody Cyclin-dependent kinase 4 inhibitor B antibody Multiple tumor suppressor 2 antibody MTS-2 antibody p14-INK4b antibody p15-INK4b antibody p15INK4B antibody |
|---|---|
| Molecular Weight(MW) | 14 kDa |
| SwissProt ID | P42772 |
|---|
| Positive Control | Heart,Skin, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
