| Product Name | p35 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CDK5R1 antibody; CDK5R antibody; NCK5A antibody; Cyclin-dependent kinase 5 activator 1 antibody; CDK5 activator 1 antibody; Cyclin-dependent kinase 5 regulatory subunit 1 antibody; TPKII regulatory subunit antibody; |
| Product description | The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDK5R1. AA range:11-60 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | CDK5R1 antibody CDK5R antibody NCK5A antibody Cyclin-dependent kinase 5 activator 1 antibody CDK5 activator 1 antibody Cyclin-dependent kinase 5 regulatory subunit 1 antibody TPKII regulatory subunit antibody |
|---|---|
| Molecular Weight(MW) | 38 kDa |
| SwissProt ID | Q15078 |
|---|
| Positive Control | Brain,Mammary gland, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
