| Product Name | p40-phox |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NCF4 antibody; SH3PXD4 antibody; Neutrophil cytosol factor 4 antibody; NCF-4 antibody; Neutrophil NADPH oxidase factor 4 antibody; SH3 and PX domain-containing protein 4 antibody; p40-phox antibody; p40phox antibody; |
| Product description | The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding d |
| Immunogen | The antiserum was produced against synthesized peptide derived from human p40 phox. AA range:120-169 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | NCF4 antibody SH3PXD4 antibody Neutrophil cytosol factor 4 antibody NCF-4 antibody Neutrophil NADPH oxidase factor 4 antibody SH3 and PX domain-containing protein 4 antibody p40-phox antibody p40phox antibody |
|---|---|
| Molecular Weight(MW) | 40 kDa |
| SwissProt ID | Q15080 |
|---|
| Positive Control | Lymph,Thymus, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
