| Product Name | PERK |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | EIF2AK3 antibody; PEK antibody; PERK antibody; Eukaryotic translation initiation factor 2-alpha kinase 3 antibody; PRKR-like endoplasmic reticulum kinase antibody; Pancreatic eIF2-alpha kinase antibody; HsPEK antibody; |
| Product description | The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EIF2AK3. AA range:947-996 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IFWBIHC |
| IF:1:50-200 WB IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | EIF2AK3 antibody PEK antibody PERK antibody Eukaryotic translation initiation factor 2-alpha kinase 3 antibody PRKR-like endoplasmic reticulum kinase antibody Pancreatic eIF2-alpha kinase antibody HsPEK antibody |
|---|---|
| Molecular Weight(MW) | 125 kDa |
| SwissProt ID | Q9NZJ5 |
|---|
| Positive Control | Brain,Fetal brain,Liver,Pancreas,Pooled,Tes |
|---|---|
| Application Notes | IF:1:50-200 WB IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
