| Product Name | PKA Iα reg |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PRKAR1A antibody; PKR1 antibody; PRKAR1 antibody; TSE1 antibody; cAMP-dependent protein kinase type I-alpha regulatory subunit antibody; Tissue-specific extinguisher 1 antibody; TSE1 antibody; |
| Product description | cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncog |
| Immunogen | The antiserum was produced against synthesized peptide derived from human KAP0. AA range:271-320 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | PRKAR1A antibody PKR1 antibody PRKAR1 antibody TSE1 antibody cAMP-dependent protein kinase type I-alpha regulatory subunit antibody Tissue-specific extinguisher 1 antibody TSE1 antibody |
|---|---|
| Molecular Weight(MW) | 43 kDa |
| SwissProt ID | P10644 |
|---|
| Positive Control | Cerebellum,Epithelium,Liver,Lymph,Platelet, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
