| Product Name | PKAα/β cat |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PRKACA antibody; PKACA antibody; cAMP-dependent protein kinase catalytic subunit alpha antibody; PKA C-alpha antibody; PRKACB antibody; cAMP-dependent protein kinase catalytic subunit beta antibody; PKA C-beta antibody; |
| Product description | This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Altern |
| Immunogen | The antiserum was produced against synthesized peptide derived from human KAPC A/B. AA range:1-50 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | PRKACA antibody PKACA antibody cAMP-dependent protein kinase catalytic subunit alpha antibody PKA C-alpha antibody PRKACB antibody cAMP-dependent protein kinase catalytic subunit beta antibody PKA C-beta antibody |
|---|---|
| Molecular Weight(MW) | 38 kDa |
| Positive Control | Amnion,Epithelium,Eye,Sperm,Testis,Thalamus, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
