| Product Name | Rad17 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RAD17 antibody; R24L antibody; Cell cycle checkpoint protein RAD17 antibody; hRad17 antibody; RF-C/activator 1 homolog antibody; |
| Product description | The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, h |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RAD17. AA range:621-670 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | RAD17 antibody R24L antibody Cell cycle checkpoint protein RAD17 antibody hRad17 antibody RF-C/activator 1 homolog antibody |
|---|---|
| Molecular Weight(MW) | 86 kDa |
| SwissProt ID | O75943 |
|---|
| Positive Control | Brain,Cervix carcinoma,Colon,Epithelium,Fetal brain,Fibroblast,Live |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
