| Product Name | Sgo1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SGOL1 antibody; SGO1 antibody; Shugoshin-like 1 antibody; hSgo1 antibody; Serologically defined breast cancer antigen NY-BR-85 antibody; |
| Product description | The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibro |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SGOL1. AA range:271-320 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | SGOL1 antibody SGO1 antibody Shugoshin-like 1 antibody hSgo1 antibody Serologically defined breast cancer antigen NY-BR-85 antibody |
|---|---|
| Molecular Weight(MW) | 64 kDa |
| SwissProt ID | Q5FBB7 |
|---|
| Positive Control | Cervix,Lung,Mammary gland, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
