| Product Name | Shank 2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SHANK2 antibody; CORTBP1 antibody; KIAA1022 antibody; SH3 and multiple ankyrin repeat domains protein 2 antibody; Shank2 antibody; Cortactin-binding protein 1 antibody; CortBP1 antibody; Proline-rich synapse-associated protein 1 antibody; |
| Product description | This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SHANK2. AA range:331-380 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | SHANK2 antibody CORTBP1 antibody KIAA1022 antibody SH3 and multiple ankyrin repeat domains protein 2 antibody Shank2 antibody Cortactin-binding protein 1 antibody CortBP1 antibody Proline-rich synapse-associated protein 1 antibody |
|---|---|
| Molecular Weight(MW) | 135 kDa |
| SwissProt ID | Q9UPX8 |
|---|
| Positive Control | Brain,Epithelium,PCR rescued clones, |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
