| Product Name | Strad |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | STRADA antibody; LYK5 antibody; STRAD antibody; STE20-related kinase adapter protein alpha antibody; STRAD alpha antibody; STE20-related adapter protein antibody; Serologically defined breast cancer antigen NY-BR-96 antibody; |
| Product description | The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human STRAD. AA range:11-60 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | STRADA antibody LYK5 antibody STRAD antibody STE20-related kinase adapter protein alpha antibody STRAD alpha antibody STE20-related adapter protein antibody Serologically defined breast cancer antigen NY-BR-96 antibody |
|---|---|
| Molecular Weight(MW) | 46 kDa |
| SwissProt ID | Q7RTN6 |
|---|
| Positive Control | Lymph node,Mammary tumor,Synovial membrane tissue,Teratocarcinoma,U |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
