| Product Name | TBC1D4 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TBC1D4 antibody; AS160 antibody; KIAA0603 antibody; TBC1 domain family member 4 antibody; Akt substrate of 160 kDa antibody; AS160 antibody; |
| Product description | This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Ph |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AS160. AA range:611-660 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCIF |
| IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | TBC1D4 antibody AS160 antibody KIAA0603 antibody TBC1 domain family member 4 antibody Akt substrate of 160 kDa antibody AS160 antibody |
|---|---|
| Molecular Weight(MW) | kDa |
| SwissProt ID | O60343 |
|---|
| Positive Control | Brain,Epithelium,Fetal liver,Placenta,Testis,Trachea, |
|---|---|
| Application Notes | IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
