| Product Name | TCF-1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TCF7 antibody; TCF1 antibody; Transcription factor 7 antibody; TCF-7 antibody; T-cell-specific transcription factor 1 antibody; T-cell factor 1 antibody; TCF-1 antibody; |
| Product description | alternative products:2 series of isoforms, L and S, are produced by use of alternative promoter usage. Additional isoforms seem to exist,Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. induction:By TCF7L2 and CTNNB1. sequence caution:Wrong choice of frame. Belongs to the TCF/LEF family. Contains 1 HMG box DNA-binding domain. subunit:Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with AES, TLE1, TLE2, TLE3 and TLE4. tissue specificity:Predominantly in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TCF7. AA range:10-59 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | TCF7 antibody TCF1 antibody Transcription factor 7 antibody TCF-7 antibody T-cell-specific transcription factor 1 antibody T-cell factor 1 antibody TCF-1 antibody |
|---|---|
| Molecular Weight(MW) | 42 kDa |
| SwissProt ID | P36402 |
|---|
| Positive Control | Liver,Skin,T-cell,T-cell lymphoma,Thymus, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
