| Product Name | TDG |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TDG antibody; G/T mismatch-specific thymine DNA glycosylase antibody; Thymine-DNA glycosylase antibody; |
| Product description | The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TDG. AA range:31-80 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | TDG antibody G/T mismatch-specific thymine DNA glycosylase antibody Thymine-DNA glycosylase antibody |
|---|---|
| Molecular Weight(MW) | 46 kDa |
| SwissProt ID | Q13569 |
|---|
| Positive Control | Colon,Lung,Pooled,Thymus, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
