| Product Name | Tensin3 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TNS3 antibody; TEM6 antibody; TENS1 antibody; TPP antibody; Tensin-3 antibody; Tensin-like SH2 domain-containing protein 1 antibody; Tumor endothelial marker 6 antibody; |
| Product description | May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development. induction:EGF induces down-regulation. PTM:Epidermal growth factor(EGF) induces tyrosine phosphorylation in a time- and dose-dependent manner. Contains 1 C2 tensin-type domain. Contains 1 phosphatase tensin-type domain. Contains 1 SH2 domain. subunit:EGF promotes the interaction with EGFR. Interacts with PTK2 and BCAR1. Tyrosine phosphorylation is critical for these interactions. tissue specificity:Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TENS3. AA range:541-590 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCIF |
| IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | TNS3 antibody TEM6 antibody TENS1 antibody TPP antibody Tensin-3 antibody Tensin-like SH2 domain-containing protein 1 antibody Tumor endothelial marker 6 antibody |
|---|---|
| Molecular Weight(MW) | kDa |
| SwissProt ID | Q68CZ2 |
|---|
| Positive Control | Amygdala,Brain,Epithelium,Kidney,Placenta,Spleen,Testis, |
|---|---|
| Application Notes | IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
