| Product Name | TOK-1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BCCIP antibody; TOK1 antibody; BRCA2 and CDKN1A-interacting protein antibody; P21- and CDK-associated protein 1 antibody; Protein TOK-1 antibody; |
| Product description | This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. |
| Immunogen | Synthesized peptide derived from TOK-1 . at AA range: 60-140 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | BCCIP antibody TOK1 antibody BRCA2 and CDKN1A-interacting protein antibody P21- and CDK-associated protein 1 antibody Protein TOK-1 antibody |
|---|---|
| Molecular Weight(MW) | 35 kDa |
| SwissProt ID | Q9P287 |
|---|
| Positive Control | Brain,Epithelium, |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
