| Product Name | Topo IIIβ-1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TOP3B antibody; TOP3B1 antibody; DNA topoisomerase 3-beta-1 antibody; DNA topoisomerase III beta-1 antibody; |
| Product description | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TOP3B. AA range:51-100 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | TOP3B antibody TOP3B1 antibody DNA topoisomerase 3-beta-1 antibody DNA topoisomerase III beta-1 antibody |
|---|---|
| Molecular Weight(MW) | 96 kDa |
| SwissProt ID | O95985 |
|---|
| Positive Control | Skin, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
