| Product Name | TRIP15 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | COPS2 antibody; CSN2 antibody; TRIP15 antibody; COP9 signalosome complex subunit 2 antibody; SGN2 antibody; Signalosome subunit 2 antibody; Alien homolog antibody; JAB1-containing signalosome subunit 2 antibody; Thyroid receptor-interacting protein 15 antibody; TR-interacting protein 15 antibody; TRIP-15 antibody; |
| Product description | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. PTM:Phosphorylated by CK2 and PKD kinases. Belongs to the CSN2 family. Contains 1 PCI domain. subunit:Interacts with NIF3L1 (By similarity). Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4, COPS5 COPS6 and COPS7 (COPS7A or COPS7B). Interacts with CUL1 and CUL2. Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human COPS2. AA range:181-230 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouseRatMonkey |
| Concentration | 1mg/ml |
| Alternative Names | COPS2 antibody CSN2 antibody TRIP15 antibody COP9 signalosome complex subunit 2 antibody SGN2 antibody Signalosome subunit 2 antibody Alien homolog antibody JAB1-containing signalosome subunit 2 antibody Thyroid receptor-interacting protein 15 antibody TR-interacting protein 15 antibody TRIP-15 antibody |
|---|---|
| Molecular Weight(MW) | 55 kDa |
| SwissProt ID | P61201 |
|---|
| Positive Control | Brain,Coronary artery,Pituitary,Skeletal muscle, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
