| Product Name | UBN-1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | UBN1 antibody; Ubinuclein-1 antibody; HIRA-binding protein antibody; Protein VT4 antibody; Ubiquitously expressed nuclear protein antibody; |
| Product description | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. Belongs to the ubinuclein family. subcellular location:Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis. subunit:Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3. 3 and UBN1. Interacts with Epstein-Barr virus BZLF1. Interacts with HIRA (via WD repeat domain); the interaction is direct. Interacts with ASF1A, CEBPA, TJP1, TJP2 and TJP3. tissue specificity:Ubiquitous. Also expressed in numerous tumors and cancer cell lines. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Ubinuclein. AA range:161-210 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | UBN1 antibody Ubinuclein-1 antibody HIRA-binding protein antibody Protein VT4 antibody Ubiquitously expressed nuclear protein antibody |
|---|---|
| Molecular Weight(MW) | kDa |
| SwissProt ID | Q9NPG3 |
|---|
| Positive Control | Cervix carcinoma,Epithelium,Placenta, |
|---|---|
| Application Notes | IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
