| Product Name | XPG |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ERCC5 antibody; ERCM2 antibody; XPG antibody; XPGC antibody; DNA repair protein complementing XP-G cells antibody; DNA excision repair protein ERCC-5 antibody; Xeroderma pigmentosum group G-complementing protein antibody; |
| Product description | This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ERCC5. AA range:131-180 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | ERCC5 antibody ERCM2 antibody XPG antibody XPGC antibody DNA repair protein complementing XP-G cells antibody DNA excision repair protein ERCC-5 antibody Xeroderma pigmentosum group G-complementing protein antibody |
|---|---|
| Molecular Weight(MW) | 130 kDa |
| SwissProt ID | P28715 |
|---|
| Positive Control | Bone marrow,Epithelium,Eye, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
