domain:The RanBP2-type zinc fingers mediate binding to RNA. Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. PTM:Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR. sequence caution:Intron retention. Belongs to the ZRANB2 family. Contains 2 RanBP2-type zinc fingers. subunit:Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of XE7 as well as with U2AF1 and CLK1.
Immunogen
The antiserum was produced against synthesized peptide derived from human ZNF265. AA range:106-155