| Product Name | Lck BP-1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HCLS1 antibody; HS1 antibody; Hematopoietic lineage cell-specific protein antibody; Hematopoietic cell-specific LYN substrate 1 antibody; LckBP1 antibody; p75 antibody; |
| Product description | developmental stage:Expressed in early stage of myeloid and erythroid differentiation. Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. PTM:Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells. Contains 1 SH3 domain. Contains 4 cortactin repeats. subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. tissue specificity:Expressed only in tissues and cells of hematopoietic origin. |
| Immunogen | Synthesized peptide derived from Lck BP-1 . at AA range: 340-420 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | HCLS1 antibody HS1 antibody Hematopoietic lineage cell-specific protein antibody Hematopoietic cell-specific LYN substrate 1 antibody LckBP1 antibody p75 antibody |
|---|---|
| Molecular Weight(MW) | 54 kDa |
| SwissProt ID | P14317 |
|---|
| Positive Control | Lymph,T-cell, |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
