| Product Name | SLAM |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SLAMF1 antibody; SLAM antibody; Signaling lymphocytic activation molecule antibody; CDw150 antibody; IPO-3 antibody; CD150 antibody; |
| Product description | domain:The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues. High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. PTM:Phosphorylated by FYN. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. subcellular location:Present on the surface of B-cells and T-cells. subunit:Its cytoplasmic domain interacts with SH2 domain protein 1A (SH2D1A), and with PTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus HN protein and acts as a receptor for this virus. tissue specificity:Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes, and a proportion of B-cells, and is rapidely induced on naive T-cells after activation. |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human SLAMF1. AA range:81-130 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-300 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | SLAMF1 antibody SLAM antibody Signaling lymphocytic activation molecule antibody CDw150 antibody IPO-3 antibody CD150 antibody |
|---|---|
| Molecular Weight(MW) | 37 kDa |
| SwissProt ID | Q13291 |
|---|
| Positive Control | Prostate,T-cell,Testis, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
