| Product Name | Amphiphysin II |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BIN1 antibody; AMPHL antibody; Myc box-dependent-interacting protein 1 antibody; Amphiphysin II antibody; Amphiphysin-like protein antibody; Box-dependent myc-interacting protein 1 antibody; Bridging integrator 1 antibody; |
| Product description | This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human BIN1. AA range:521-570 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | BIN1 antibody AMPHL antibody Myc box-dependent-interacting protein 1 antibody Amphiphysin II antibody Amphiphysin-like protein antibody Box-dependent myc-interacting protein 1 antibody Bridging integrator 1 antibody |
|---|---|
| Molecular Weight(MW) | 65 kDa |
| SwissProt ID | O00499 |
|---|
| Positive Control | Brain,Epithelium,Fibroblast,Pancreas,Skeletal muscle,Whole brain, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
