| Product Name | HLA-DQB1/2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HLA-DQB1 antibody; HLA-DQB antibody; HLA class II histocompatibility antigen, DQ beta 1 chain antibody; MHC class II antigen DQB1 antibody; HLA-DQB2 antibody; HLA-DXB antibody; HLA class II histocompatibility antigen, DQ beta 2 chainHLA class II histocompatibility antigen, DX beta chain antibody; MHC class II antigen DQB2 antibody; |
| Product description | HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marro |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human HLA-DQB1/HLA-DQB2. AA range:131-180 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | HLA-DQB1 antibody HLA-DQB antibody HLA class II histocompatibility antigen DQ beta 1 chain antibody MHC class II antigen DQB1 antibody HLA-DQB2 antibody HLA-DXB antibody HLA class II histocompatibility antigen DQ beta 2 chainHLA class II histocompatibility antigen DX beta chain antibody MHC class II antigen DQB2 antibody |
|---|---|
| Molecular Weight(MW) | 30 kDa |
| Positive Control | B-cell,Blood,Colon,Peripheral blood,Peripheral bloo |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
