| Product Name | Neuregulin-3 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NRG3 antibody; Pro-neuregulin-3, membrane-bound isoform antibody; Pro-NRG3 antibody; |
| Product description | This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcri |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human NRG3. AA range:311-360 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | NRG3 antibody Pro-neuregulin-3 membrane-bound isoform antibody Pro-NRG3 antibody |
|---|---|
| Molecular Weight(MW) | 80 kDa |
| SwissProt ID | P56975 |
|---|
| Positive Control | Brain,Fetal brain,Testicle, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
