| Product Name | ASAH3 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ACER1 antibody; ASAH3 antibody; Alkaline ceramidase 1 antibody; AlkCDase 1 antibody; Alkaline CDase 1 antibody; Acylsphingosine deacylase 3 antibody; N-acylsphingosine amidohydrolase 3 antibody; |
| Product description | Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al. 2006 |
| Immunogen | Synthesized peptide derived from ASAH3 . at AA range: 100-180 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | ACER1 antibody ASAH3 antibody Alkaline ceramidase 1 antibody AlkCDase 1 antibody Alkaline CDase 1 antibody Acylsphingosine deacylase 3 antibody N-acylsphingosine amidohydrolase 3 antibody |
|---|---|
| Molecular Weight(MW) | 34 kDa |
| SwissProt ID | Q8TDN7 |
|---|
| Application Notes | WB:1:500-1:2000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
