| Product Name | CYFIP2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121) antibody; |
| Product description | disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level). Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA. induction:By p53. RNA editing:Partially edited. Editing appears to be brain-specific. Belongs to the CYFIP family. subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus. subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. |
| Immunogen | Synthesized peptide derived from CYFIP2 at AA range: 1171-1220 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121) antibody |
|---|---|
| Molecular Weight(MW) | 150/45 kDa |
| SwissProt ID | Q96F07 |
|---|
| Positive Control | Amygdala,Blood,Brain,Hippocampus,Liver,Lymph, |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
