Application
Fig1: Western blot analysis of MVP on A549 (1) and Hela (2) cell lysate using anti-MVP antibody at 1/1,000 dilution.Application
Fig2: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-MVP antibody. Counter stained with hematoxylin.Application
Fig3: Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue using anti-MVP antibody. Counter stained with hematoxylin.Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-MVP antibody. Counter stained with hematoxylin.| Product Name | MVP [JM74-73] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LRP antibody Lung resistance related protein antibody Lung resistance-related protein antibody Major vault protein antibody Major vault protein, rat, homolog of antibody MVP antibody MVP_HUMAN antibody testicular secretory protein Li 30 antibody VAULT 1 antibody VAULT1 antibody |
| Product description | Major vault protein (MVP), is overexpressed in various multidrug-resistant cancer cell lines and clinical samples. The promoter of MVP is TATA-less; contains an inverted CCAAT-box and a Sp1 site located near a p53 binding motif. MVP has two alternative splice variants, which differ from each other within the 5'-leader. The long-MVP isoform is ubiquitously expressed and represents an almost constant portion of the total MVP mRNA in many different normal tissues. MVP is the major component of the multimeric ribonucleoprotein complexes, with several copies of an untranslated RNA, which has been shown to transport along cytoskeletal-based cellular tracks. In conclusion, MVP protein mediates drug resistance, perhaps via a transport process. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:1,000 IHC |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | LRP antibody
Lung resistance related protein antibody
Lung resistance-related protein antibody
Major vault protein antibody
Major vault protein rat homolog of antibody MVP antibody MVP_HUMAN antibody testicular secretory protein Li 30 antibody VAULT 1 antibody VAULT1 antibody |
|---|---|
| Molecular Weight(MW) | 99 kDa |
| Cellular Localization | Cytoplasm. Nucleus. Membrane. |
Application
Fig1: Western blot analysis of MVP on A549 (1) and Hela (2) cell lysate using anti-MVP antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-MVP antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue using anti-MVP antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-MVP antibody. Counter stained with hematoxylin.| Positive Control | Hela, A549, human colon cancer tissue, human stomach cancer tissue, mouse colon tissue. |
|---|---|
| Application Notes | WB:1:500-1:1,000 IHC |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
