Application
Fig1: Western blot analysis of Frizzled 8 on mouse lung tissue lysates using anti-Frizzled 8 antibody at 1/500 dilution.Application
Fig2: Immunohistochemical analysis of paraffin-embedded human uterus tissue using anti-Frizzled 8 antibody. Counter stained with hematoxylin.Application
Fig3: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Frizzled 8 antibody. Counter stained with hematoxylin.| Product Name | Frizzled 8 [JB40-16] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Frizzled 8 seven transmembrane spanning receptor antibody frizzled 8, seven transmembrane spanning receptor antibody Frizzled family receptor 8 antibody frizzled homolog 8 (Drosophila) antibody Frizzled homolog 8 antibody Frizzled-8 antibody FZ 8 antibody Fz-8 antibody FZ8 antibody FZD 8 antibody FZD8 antibody FZD8_HUMAN antibody hFZ 8 antibody hFz8 antibody HGNC4046 antibody Homolog of Drosophila Frizzled 8 antibody |
| Product description | Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:1,000 IHC:1:50-1:100 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | Frizzled 8 seven transmembrane spanning receptor antibody
frizzled 8 seven transmembrane spanning receptor antibody Frizzled family receptor 8 antibody frizzled homolog 8 (Drosophila) antibody Frizzled homolog 8 antibody Frizzled-8 antibody FZ 8 antibody Fz-8 antibody FZ8 antibody FZD 8 antibody FZD8 antibody FZD8_HUMAN antibody hFZ 8 antibody hFz8 antibody HGNC4046 antibody Homolog of Drosophila Frizzled 8 antibody |
|---|---|
| Molecular Weight(MW) | Predicted band size 73 kDa |
| Cellular Localization | Golgi apparatus. Membrane. |
| SwissProt ID | Q9H461 |
|---|
Application
Fig1: Western blot analysis of Frizzled 8 on mouse lung tissue lysates using anti-Frizzled 8 antibody at 1/500 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human uterus tissue using anti-Frizzled 8 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Frizzled 8 antibody. Counter stained with hematoxylin.| Positive Control | Mouse lung tissue lysates, Human kidney tissue, human uterus tissue. |
|---|---|
| Application Notes | WB:1:500-1:1,000 IHC:1:50-1:100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
