Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-DSG1 antibody. Counter stained with hematoxylin.Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-DSG1 antibody. Counter stained with hematoxylin.Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-DSG1 antibody. Counter stained with hematoxylin.Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-DSG1 antibody. Counter stained with hematoxylin.| Product Name | DSG1 [JB19-46] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Cadherin family member 4 antibody CDHF4 antibody Desmoglein-1 antibody Desmosomal glycoprotein 1 antibody DG1 antibody DGI antibody DSG antibody DSG1 antibody DSG1_HUMAN antibody EPKHE antibody EPKHIA antibody Pemphigus foliaceus antigen antibody PPKS1 antibody SPPK1 antibody |
| Product description | Desmogleins (dsgs) are type I membrane proteins that are important for cell adhesion and are expressed in great abundance at the desmosomes, which are adhesive cell junctions. The dsg proteins belong to the cadherin family and consist of dsg1, dsg2 and dsg3. Calcium binds to the putative calcium binding sites at the extracellular N-terminal domain of dsg1, which has cadherin-like repeats. Unlike normal human keratinocytes, the squamous cell carcinoma cells exhibit diminished or unusual expression of dsg3 and dsg1, which bear pemphigus vulgaris and pemphigus foliaceus antigens, respectively. Cultured normal human keratinocytes express dsg1 and dsg3 mRNA, with or without dsg 2 mRNA, which indicates that desmoglein isoforms exhibit abnormal expression and may be related to tumor cell kinetics, such as cell invasion and metastasis. Pemphigus is an autoimmune disease of skin adhesion associated with auto-antibodies against a number of keratinocyte antigens, such as the adhesion molecules dsg 1 and 3 and acetylcholine receptors. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| IHC:1:50-1:200 WB:1:500 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | Cadherin family member 4 antibody CDHF4 antibody Desmoglein-1 antibody Desmosomal glycoprotein 1 antibody DG1 antibody DGI antibody DSG antibody DSG1 antibody DSG1_HUMAN antibody EPKHE antibody EPKHIA antibody Pemphigus foliaceus antigen antibody PPKS1 antibody SPPK1 antibody |
|---|---|
| Molecular Weight(MW) | Predicted band size 114 kDa |
| Cellular Localization | Cell membrane. |
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-DSG1 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-DSG1 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-DSG1 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-DSG1 antibody. Counter stained with hematoxylin.| Positive Control | Human colon cancer tissue, human skin tissue, human uterus tissue, mouse skin tissue. |
|---|---|
| Application Notes | IHC:1:50-1:200 WB:1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
