Application
Fig1: Western blot analysis on (A) MCF-7 and (B) SKBR3 cell lysate using anti-cathepsin D.Application
Fig2： Immunohistochemical analysis of paraffin-embedded human liver using anti-Cathepsin D.| Product Name | Cathepsin D |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CatD antibody CATD_HUMAN antibody Cathepsin D antibody Cathepsin D heavy chain antibody CD antibody Ceroid lipofuscinosis neuronal 10 antibody CLN10 antibody CPSD antibody ctsd antibody Epididymis secretory sperm binding protein Li 130P antibody HEL S 130P antibody Lysosomal aspartyl peptidase antibody Lysosomal aspartyl protease antibody MGC2311 antibody |
| Product description | Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis (1). It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and breast cancer progression (2). Cathepsin D is induced by estrogens in mammary cancer cells where its concentration is correlated with a higher risk of metastasis (3). It is possibly involved in Alzheimer's disease-related neurodegeneration through cleavage of amyloid precursor protein into amyloidogenic components (4). Preprocathepsin D (43 kDa) is cleaved and glycosylated to form procathepsin D (46 kDa), and then further cleaved, forming light and a heavy chains (15 kDa and 28 kDa, respectively) (5). |
| Immunogen | peptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBICCIHC |
| WB:1:1,000 ICC:1:100-250 IHC:1:100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | CatD antibody CATD_HUMAN antibody Cathepsin D antibody Cathepsin D heavy chain antibody CD antibody Ceroid lipofuscinosis neuronal 10 antibody CLN10 antibody CPSD antibody ctsd antibody Epididymis secretory sperm binding protein Li 130P antibody HEL S 130P antibody Lysosomal aspartyl peptidase antibody Lysosomal aspartyl protease antibody MGC2311 antibody |
|---|---|
| Molecular Weight(MW) | 46/15kDa |
| Cellular Localization | Lysosome, Melanosome, Secreted |
| SwissProt ID | P07339 |
|---|
Application
Fig1: Western blot analysis on (A) MCF-7 and (B) SKBR3 cell lysate using anti-cathepsin D.
Application
Fig2： Immunohistochemical analysis of paraffin-embedded human liver using anti-Cathepsin D.| Positive Control | MCF-7, SKBR3 |
|---|---|
| Application Notes | WB:1:1,000 ICC:1:100-250 IHC:1:100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20 ℃. Stable for 12 months from date of receipt |
| Storage Buffer | 1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
