Application
Fig1: Western blot analysis on MCF-7 cell lysate using anti-Cyclin D1.Application
Fig2： Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma using anti-Cyclin D1.| Product Name | Cyclin D1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AI327039 antibody B cell CLL/lymphoma 1 antibody B cell leukemia 1 antibody B cell lymphoma 1 protein antibody B-cell lymphoma 1 protein antibody BCL 1 antibody BCL-1 antibody BCL-1 oncogene antibody BCL1 antibody BCL1 oncogene antibody ccnd1 antibody CCND1/FSTL3 fusion gene, included antibody CCND1/IGHG1 fusion gene, included antibody CCND1/IGLC1 fusion gene, included antibody CCND1/PTH fusion gene, included antibody CCND1_HUMAN antibody cD1 antibody Cyl 1 antibody D11S287E antibody G1/S specific cyclin D1 antibody G1/S-specific cyclin-D1 antibody Parathyroid adenomatosis 1 antibody PRAD1 antibody PRAD1 oncogene antibody U21B31 antibody |
| Product description | Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition (1). Cyclin D1 forms a serine/threonine kinase holoenzyme complex with and functions as a regulatory subunit of CDK4 or CDK6. Cyclin D1 also phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1/S phase (2-3). Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer (4-5). Over-expression of cyclin D1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis (6). Cyclin D1 also associates with, and regulates the activity of transcription factors, coactivators and corepressors that govern histone acetylation and chromatin remodeling proteins (7-8). |
| Immunogen | peptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBICCIHCIP |
| WB:1:1,000 ICC:1:50-100 IHC:1:100-250 IP:1:10-100 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | AI327039 antibody
B cell CLL/lymphoma 1 antibody
B cell leukemia 1 antibody
B cell lymphoma 1 protein antibody
B-cell lymphoma 1 protein antibody
BCL 1 antibody
BCL-1 antibody
BCL-1 oncogene antibody
BCL1 antibody
BCL1 oncogene antibody
ccnd1 antibody
CCND1/FSTL3 fusion gene included antibody CCND1/IGHG1 fusion gene included antibody CCND1/IGLC1 fusion gene included antibody CCND1/PTH fusion gene included antibody CCND1_HUMAN antibody cD1 antibody Cyl 1 antibody D11S287E antibody G1/S specific cyclin D1 antibody G1/S-specific cyclin-D1 antibody Parathyroid adenomatosis 1 antibody PRAD1 antibody PRAD1 oncogene antibody U21B31 antibody |
|---|---|
| Molecular Weight(MW) | 36kDa |
| Cellular Localization | Cytoplasm, Nucleus, Membrane |
| SwissProt ID | P24385 |
|---|
Application
Fig1: Western blot analysis on MCF-7 cell lysate using anti-Cyclin D1.
Application
Fig2： Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma using anti-Cyclin D1.| Positive Control | MCF-7. |
|---|---|
| Application Notes | WB:1:1,000 ICC:1:50-100 IHC:1:100-250 IP:1:10-100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20 ℃. Stable for 12 months from date of receipt |
| Storage Buffer | 1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
