Application
Fig1: Western blot analysis on (A) A375, (B) A431, (C) SW480, and (D) HeLa cell lysates using anti-MSH2.| Product Name | MSH2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BAT26 antibody COCA 1 antibody COCA1 antibody DNA mismatch repair protein Msh2 antibody FCC 1 antibody FCC1 antibody hMSH2 antibody HNPCC 1 antibody HNPCC antibody HNPCC1 antibody LCFS2 antibody MSH 2 antibody Msh2 antibody MSH2_HUMAN antibody MutS homolog 2 antibody MutS homolog 2 colon cancer nonpolyposis type 1 antibody MutS protein homolog 2 antibody |
| Product description | MutS homologue 2 (MSH2) is a DNA mismatch repair protein in the MutS family (1). MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6) and MutS beta (MSH2-MSH3) that bind to DNA mismatches thereby initiating DNA repair. (2). MutS alpha bends the DNA helix and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA (2). MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long (2). Heterozygous mutations in the MSH2 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 and MSH6 (3, 4). MutS alpha may also play a role in DNA homologous recombination repair (2). |
| Immunogen | peptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBFC |
| WB:1:1,000 FC:1:10-100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | BAT26 antibody COCA 1 antibody COCA1 antibody DNA mismatch repair protein Msh2 antibody FCC 1 antibody FCC1 antibody hMSH2 antibody HNPCC 1 antibody HNPCC antibody HNPCC1 antibody LCFS2 antibody MSH 2 antibody Msh2 antibody MSH2_HUMAN antibody MutS homolog 2 antibody MutS homolog 2 colon cancer nonpolyposis type 1 antibody MutS protein homolog 2 antibody |
|---|---|
| Molecular Weight(MW) | 100 kDa |
| Cellular Localization | Nucleus |
| SwissProt ID | P43246 |
|---|
Application
Fig1: Western blot analysis on (A) A375, (B) A431, (C) SW480, and (D) HeLa cell lysates using anti-MSH2.| Positive Control | Hela, A375, A431, SW480. |
|---|---|
| Application Notes | WB:1:1,000 FC:1:10-100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20 ℃. Stable for 12 months from date of receipt |
| Storage Buffer | 1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
