Application
Fig1: Western blot analysis on (A) A431, (B) HeLa, and (C) SW480 cell lysates using anti-MSH6.Application
Fig2： Immunohistochemical analysis of paraffin-embedded human colonic adenocarcinoma tissue using anti-MSH6.| Product Name | MSH6 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DNA mismatch repair protein Msh6 antibody G/T mismatch binding protein antibody G/T mismatch-binding protein antibody GTBP antibody GTMBP antibody hMSH6 antibody HNPCC 5 antibody HNPCC5 antibody HSAP antibody MSH 6 antibody MSH6 antibody MSH6_HUMAN antibody mutS (E. coli) homolog 6 antibody MutS alpha 160 kDa subunit antibody MutS homolog 6 (E. coli) antibody mutS homolog 6 antibody MutS-alpha 160 kDa subunit antibody p160 antibody Sperm associated protein antibody |
| Product description | The MutS homologue 6 protein (MSH6) is a member of the MutS homolog family required in the DNA mismatch repair system (1). MSH6 forms a MutS alpha dimer with MSH2, binding to DNA mismatches to initiate DNA repair (2). MutS alpha bends the DNA helix and recognizes single base mismatches and dinucleotide insertion-deletion loops in the DNA (2). Heterozygous mutations in the MSH6 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 (3, 4). The frequency of MSH6 mutation is higher in HNPCC than in atypical HNPCC (5). The MSH2/MSH6 dimer may also play a role in DNA homologous recombination repair (2). |
| Immunogen | peptide |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBICCIHC |
| WB:1:1,000 IP:1:10-100 IHC:1:100-250 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | DNA mismatch repair protein Msh6 antibody G/T mismatch binding protein antibody G/T mismatch-binding protein antibody GTBP antibody GTMBP antibody hMSH6 antibody HNPCC 5 antibody HNPCC5 antibody HSAP antibody MSH 6 antibody MSH6 antibody MSH6_HUMAN antibody mutS (E. coli) homolog 6 antibody MutS alpha 160 kDa subunit antibody MutS homolog 6 (E. coli) antibody mutS homolog 6 antibody MutS-alpha 160 kDa subunit antibody p160 antibody Sperm associated protein antibody |
|---|---|
| Molecular Weight(MW) | 160 kDa |
| Cellular Localization | Nucleus, Chromosome |
| SwissProt ID | P52701 |
|---|
Application
Fig1: Western blot analysis on (A) A431, (B) HeLa, and (C) SW480 cell lysates using anti-MSH6.
Application
Fig2： Immunohistochemical analysis of paraffin-embedded human colonic adenocarcinoma tissue using anti-MSH6.| Positive Control | Hela, A431, SW480, human colonic adenocarcinoma tissue. |
|---|---|
| Application Notes | WB:1:1,000 IP:1:10-100 IHC:1:100-250 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20 ℃. Stable for 12 months from date of receipt |
| Storage Buffer | 1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
