Application
Fig1: Western blot analysis on Jurkat cell lysate using anti-Sir2.Application
Fig2： Immunohistochemical analysis of paraffin-embedded human colon carcinoma using anti-Sir-2.| Product Name | Sir2/SIRT1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres antibody MAR1 antibody NAD dependent histone deacetylase SIR2 antibody Regulatory protein SIR2 antibody Silent information regulator 2 antibody Sir2p antibody |
| Product description | The S. cerevisiae silent information regulator 2 (Sir2) protein is an NAD+-dependent histone deacetylase (HDACs) that plays a critical role in transcriptional silencing, genome stability, and longevity (1-2). Part of the Sirtuin family (Sir2, Sir3, Sir3), yeast Sir2 is the founding member of Class III HDACs. A human homologue of Sir2, SIRT1, regulates the activity of the p53 tumor suppressor and inhibits apoptosis (3-4). |
| Immunogen | peptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBICCIHCIP |
| WB:1:1,000 ICC:1:100 IHC:1:100 IP:1:50 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan plays roles in silencing at HML HMR telomeres antibody MAR1 antibody NAD dependent histone deacetylase SIR2 antibody Regulatory protein SIR2 antibody Silent information regulator 2 antibody Sir2p antibody |
|---|---|
| Molecular Weight(MW) | 110kDa |
| Cellular Localization | Cytoplasm, Nucleus, Mitochondrion |
| SwissProt ID | Q96EB6 |
|---|
Application
Fig1: Western blot analysis on Jurkat cell lysate using anti-Sir2.
Application
Fig2： Immunohistochemical analysis of paraffin-embedded human colon carcinoma using anti-Sir-2.| Positive Control | Jurkat |
|---|---|
| Application Notes | WB:1:1,000 ICC:1:100 IHC:1:100 IP:1:50 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20 ℃. Stable for 12 months from date of receipt |
| Storage Buffer | 1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
