Application
Fig1: A. Western blot analysis of FAS expression in rat thymus tissue extract.| Product Name | CD95 / Fas |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ALPS1A antibody APO 1 antibody APO 1 cell surface antigen antibody Apo-1 antigen antibody APO1 antibody Apo1 antigen antibody Apoptosis antigen 1 antibody Apoptosis mediating surface antigen FAS antibody Apoptosis-mediating surface antigen FAS antibody APT1 antibody CD95 antibody CD95 antigen antibody Fas AMA antibody Fas antibody Fas antigen antibody FAS1 antibody FASLG receptor antibody FASTM antibody TNF receptor superfamily member 6 antibody TNFRSF6 antibody TNR6_HUMAN antibody Tumor necrosis factor receptor superfamily member 6 antibody |
| Product description | Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno-surveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (also designated APO-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FAS may be critically involved in CTL-mediated cytotoxicity. |
| Immunogen | peptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCICCIP |
| WB:1:1,000 ICC:1:50-500 IHC:1:50-500 IP:1-2 μg per 100-500 μg of total protein |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | ALPS1A antibody APO 1 antibody APO 1 cell surface antigen antibody Apo-1 antigen antibody APO1 antibody Apo1 antigen antibody Apoptosis antigen 1 antibody Apoptosis mediating surface antigen FAS antibody Apoptosis-mediating surface antigen FAS antibody APT1 antibody CD95 antibody CD95 antigen antibody Fas AMA antibody Fas antibody Fas antigen antibody FAS1 antibody FASLG receptor antibody FASTM antibody TNF receptor superfamily member 6 antibody TNFRSF6 antibody TNR6_HUMAN antibody Tumor necrosis factor receptor superfamily member 6 antibody |
|---|---|
| Molecular Weight(MW) | 48 kDa |
| Cellular Localization | Membrane |
| SwissProt ID | P25446 |
|---|
Application
Fig1: A. Western blot analysis of FAS expression in rat thymus tissue extract.| Positive Control | rat thymus tissue. |
|---|---|
| Application Notes | WB:1:1,000 ICC:1:50-500 IHC:1:50-500 IP:1-2 μg per 100-500 μg of total protein |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
