Application
Fig1: Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules.| Product Name | JAK2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | JAK 2 antibody JAK-2 antibody JAK2 antibody JAK2_HUMAN antibody Janus Activating Kinase 2 antibody Janus kinase 2 (a protein tyrosine kinase) antibody Janus kinase 2 antibody JTK 10 antibody JTK10 antibody kinase Jak2 antibody OTTHUMP00000043260 antibody THCYT3 antibody Tyrosine protein kinase JAK2 antibody Tyrosine-protein kinase JAK2 antibody |
| Product description | JAK2 (Janus kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies |
| Immunogen | A peptide mapping at the C-terminus of JAK2 of mouse origin |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHC-P |
| WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein (1 ml of cell lysate) IF:1:50-1:500 IHC:1:50-1:500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | JAK 2 antibody JAK-2 antibody JAK2 antibody JAK2_HUMAN antibody Janus Activating Kinase 2 antibody Janus kinase 2 (a protein tyrosine kinase) antibody Janus kinase 2 antibody JTK 10 antibody JTK10 antibody kinase Jak2 antibody OTTHUMP00000043260 antibody THCYT3 antibody Tyrosine protein kinase JAK2 antibody Tyrosine-protein kinase JAK2 antibody |
|---|---|
| Molecular Weight(MW) | 128kDa |
| Cellular Localization | Cytoplasm, Nucleus, Endomembrane system |
| SwissProt ID | O60674 |
|---|
Application
Fig1: Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules.| Positive Control | human kidney tissue |
|---|---|
| Application Notes | WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein (1 ml of cell lysate) IF:1:50-1:500 IHC:1:50-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃, “DO NOT FREEZE”. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
