| Gene Symbol |
SNCA
|
| Gene Synonyms |
SYUA
SNCA
PD1
NACP
PARK1
PARK4 |
| Gene Full Name |
synuclein alpha |
| Gene Summary |
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016] |
| Cellular Localization |
Amyloid, Cell junction, Cytoplasm, Membrane, Nucleus, Secreted, Synapse |
