| Gene Symbol |
LRRK2
|
| Gene Synonyms |
PARK8
RIPK7
ROCO2
AURA17
DARDARIN |
| Gene Full Name |
leucine rich repeat kinase 2 |
| Gene Summary |
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. |
| Molecular Weight(MW) |
286 kDa |
| Cellular Localization |
Cell junction, Cell projection, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, Mitochondrion, Mitochondrion outer membrane, Synapse |
