| Gene Symbol |
LRRK2
|
| Gene Synonyms |
PARK8 RIPK7 ROCO2 AURA17 DARDARIN |
| Gene Full Name |
leucine rich repeat kinase 2 |
| Gene Summary |
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008] |
| Alternative Names |
augmented in rheumatoid arthritis 17 AURA17 Dardarin Leucine rich repeat kinase 2 leucine rich repeat serine threonine protein kinase 2 Leucine-rich repeat serine/threonine-protein kinase 2 LRRK 2 LRRK2 LRRK2_HUMAN PARK 8 PARK8 RIPK7 ROCO 2 ROCO2 |
| Molecular Weight(MW) |
286 kDa |
| Cellular Localization |
Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, Mitochondrion, Mitochondrion outer membrane, Synapse. |