ICC/IF
Immunofluorescent analysis of (-20°C Methanol) fixed HepG2 cells using Omnimabs® 488 Lamin A/C antibody at dilution of 1:200.| Product Name | Omnimabs® 488-conjugated Lamin A/C Recombinant antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Recombinant human Lamin A/C protein |
| Clonality | monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IF |
| ICC/IF:1:50-1:500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | LMNA |
|---|---|
| Gene Synonyms | FPL IDC LFP CDDC EMD2 FPLD HGPS LDP1 LMN1 LMNC MADA PRO1 CDCD1 CMD1A FPLD2 LMNL1 CMT2B1 LGMD1B |
| Gene Full Name | lamin A/C |
| Gene Summary | The protein encoded by this gene is part of the nuclear lamina, a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, May 2022] |
| Alternative Names | LaminA/C 5I16 lamin A Lamin-A/C LMN1 |
| Molecular Weight(MW) | 65kDa |
| Cellular Localization | Intermediate filament,Nucleus. |
ICC/IF
Immunofluorescent analysis of (-20°C Methanol) fixed HepG2 cells using Omnimabs® 488 Lamin A/C antibody at dilution of 1:200.| Application Notes | ICC/IF:1:50-1:500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20°C. Stable for one year after shipment. |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
