WB
Arious whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-NOTCH3 antibody. The HRP-conjugated Goat anti-Rabbit IgG (H + L) antibody was used to detect the antibody. Lane 1: Hela.| Product Name | NOTCH3 Rabbit mAb |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:1000-1:5000 |
|
| Species Reactivity | HumanRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | NOTCH3 |
|---|---|
| Gene Synonyms | IMF2 LMNS CASIL FPLD1 CADASIL CADASIL1 CARASIL1 |
| Gene Full Name | notch receptor 3 |
| Gene Summary | This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008] |
| Alternative Names | Neurogenic locus notch homolog protein 3 Notch 3 [Cleaved into: Notch 3 extracellular truncation Notch 3 intracellular domain] |
| Molecular Weight(MW) | 244kDa(Observed 90kDa 270kDa) |
| Cellular Localization | Cell membrane ; Single-pass type I membrane protein.; [Notch 3 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus. |
WB
Arious whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-NOTCH3 antibody. The HRP-conjugated Goat anti-Rabbit IgG (H + L) antibody was used to detect the antibody. Lane 1: Hela.| Application Notes | WB:1:1000-1:5000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Storage Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA. |
