| Product Name | Anti-Phospho-NOTCH3 (Ser84) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Ser84 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NOTCH3 |
|---|---|
| Gene Synonyms | IMF2 LMNS CASIL FPLD1 CADASIL CADASIL1 CARASIL1 |
| Gene Full Name | notch receptor 3 |
| Gene Summary | This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008] |
| Alternative Names | CADASIL CASIL NOTC3_HUMAN Notch 3 Notch 3 intracellular domain Notch homolog 3 Notch3 |
| Molecular Weight(MW) | 244 kDa |
| Cellular Localization | Cell membrane,Membrane,Nucleus. |
| SwissProt ID | Q9UM47 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
