| Gene Symbol |
EPCAM
|
| Gene Synonyms |
ESA KSA M4S1 MK-1 DIAR5 EGP-2 EGP40 KS1/4 MIC18 TROP1 BerEp4 EGP314 HNPCC8 LYNCH8 MOC-31 Ber-Ep4 TACSTD1 |
| Gene Full Name |
epithelial cell adhesion molecule |
| Gene Summary |
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008] |
| Alternative Names |
Adenocarcinoma associated antigen CD326 CD326 antigen Cell surface glycoprotein Trop 1 CO17 1A EGP EGP40 Ep CAM Epithelial cell surface antigen Epithelial cellular adhesion molecule Epithelial glycoprotein GA733 2 hEGP 2 KS 1/4 antigen KSA Lymphocyte antigen 74 M1S2 M4S1 Major gastrointestinal tumor associated protein GA733 2 MIC18 MK 1 TACD1 TACSTD1 TROP1 Tumor associated calcium signal transducer 1. |
| Molecular Weight(MW) |
35 kDa |
| Cellular Localization |
Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Co-localizes with CLDN7 at the lateral cell membrane and tight junction. |