| Product Name | Monoclonal Antibody to Telomerase Reverse Transcriptase (TERT) |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Recombinant TERT (Thr673~His976) expressed in E.coli |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a,k |
| Host Species | Mouse |
| Tested Applications | ICC/IFIHCIPWB |
| WB:0.5-2µg/mL IHC:5-20µg/mL ICC/IF:5-20µg/mL IP:1:10-1:100 |
|
| Species Reactivity | Rat |
| Concentration | 1mg/ml |
| Purification | Protein A/G |
| Gene Symbol | TERT |
|---|---|
| Gene Synonyms | TP2 TRT CMM9 EST2 TCS1 hTRT DKCA2 DKCB4 hEST2 PFBMFT1 |
| Gene Full Name | telomerase reverse transcriptase |
| Gene Summary | Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008] |
| Alternative Names | EST2 TCS1 TP2 TRT hEST2 Telomerase catalytic subunit Telomerase-associated protein 2 |
| Application Notes | WB:0.5-2µg/mL IHC:5-20µg/mL ICC/IF:5-20µg/mL IP:1:10-1:100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 24 months. |
| Storage Buffer | Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300,50% glycerol. |
